Promotes in vitro the polymerization of tubulin into double-walled tubules and polymorphic aggregates or bundled stabilized microtubules blocks. When overexpressed, inhibits mitotic spindle assembly and nuclear envelope breakdown, apparently without affecting other cellular events. PTM:Phosphorylated by TPK II. Poor substrate for GSK3. Belongs to the TPPP family. subunit:May form dimers. Binds tubulin; binding is inhibited by GTP. Interacts with GSK3. tissue specificity:Widely expressed.
Immunogen
Synthesized peptide derived from human protein . at AA range: 10-90