| Product Name | CDA7L |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line. miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation. subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction. subunit:Interacts with MYC and PSIP1. tissue specificity:Ubiquitous. Overexpressed in medulloblastoma. |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 140-220 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Molecular Weight(MW) | 49 kDa |
|---|
| SwissProt ID | Q96GN5 |
|---|
| Positive Control | Epithelium,Eye,Lung,Melanoma,Muscle,Testis, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
