Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. PTM:Phosphorylated on tyrosine residues by EGFR. Contains 1 EF-hand domain. Contains 3 EH domains. subcellular location:Localized to plasma membrane coated pits. subunit:Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2).
Immunogen
Synthesized peptide derived from human protein . at AA range: 350-430