Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. PTM:Phosphorylated on serine and tyrosine residues. sequence caution:Wrong choice of frame. Belongs to the SNF2/RAD54 helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 2 chromo domains. subunit:Interacts with PPARA. Probably interacts with ESR1 and NR1I3. tissue specificity:Widely expressed at low levels. In bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts.
Immunogen
Synthesized peptide derived from part region of human protein