catalytic activity:Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate. domain:The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+). enzyme regulation:Stimulated by cytosolic Ca(2+). Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine. Contains 1 C2 domain. Contains 1 PLA2c domain. subcellular location:Translocates to lysosomal membranes in a calcium-dependent fashion.
Immunogen
Synthesized peptide derived from part region of human protein