domain:The DHR-2 domain is necessary for the GEF activity. Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. miscellaneous:'Zizim' means 'spike' in Hebrew. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Belongs to the DOCK family. Contains 1 DHR-1 (CZH-1) domain. Contains 1 DHR-2 (CZH-2) domain. Contains 1 PH domain. subunit:Interacts with CDC42.
Immunogen
Synthesized peptide derived from part region of human protein