catalytic activity:Pyruvate + lipoyllysine = S-acetyldihydrolipoyllysine + CO(2). cofactor:Thiamine pyrophosphate. enzyme regulation:E1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit. The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). subunit:Tetramer of 2 alpha and 2 beta subunits. tissue specificity:Testis. Expressed in postmeiotic spermatogenic cells.
Immunogen
Synthesized peptide derived from human protein . at AA range: 310-390