Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac. sequence caution:Translated as Cys. Contains 1 BAR domain. Contains 1 Rho-GAP domain.
Immunogen
Synthesized peptide derived from human protein . at AA range: 170-250