domain:An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. Implicated in endocytosis. May recruit other proteins to membranes with high curvature. Belongs to the endophilin family. Contains 1 BAR domain. Contains 1 SH3 domain. subcellular location:Associated with postsynaptic endosomes in hippocampal neurons. Associated with presynaptic endosomes in olfactory neurons. subunit:Interacts with ARC (By similarity). Interacts with DNM1, SGIP1 and SYNJ1. Interacts with the huntingtin exon 1 protein (HDEX1P) containing a glutamine repeat in the pathological range and promotes formation of insoluble polyglutamine-containing aggregates in vivo. tissue specificity:Brain and testis.
Immunogen
Synthesized peptide derived from part region of human protein