| Product description |
catalytic activity:ATP + a protein = ADP + a phosphoprotein. domain:The C1 domain does not bind the diacylglycerol (DAG). enzyme regulation:Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation. Contributes to invasiveness in malignant prostate cancer. PTM:Autophosphorylated. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 3 REM (Hr1) repeats. subcellular location:Nuclear and perinuclear Golgi region. tissue specificity:Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues. |
