| Product description |
domain:The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted. Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. induction:By EGF. Contains 17 LRR (leucine-rich) repeats. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. subunit:Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4. tissue specificity:Widely expressed. |