| Product Name | Abl1/2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ABL1 antibody; ABL antibody; JTK7 antibody; Tyrosine-protein kinase ABL1 antibody; Abelson murine leukemia viral oncogene homolog 1 antibody; Abelson tyrosine-protein kinase 1 antibody; Proto-oncogene c-Abl antibody; p150 antibody; ABL2 antibody; ABLL antibody; ARG antibody; Abelson tyrosine-protein kinase 2 antibody; Abelson murine leukemia vira antibody; |
| Product description | This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [pr |
| Immunogen | The antiserum was produced against synthesized peptide derived from human c-Abl. AA range:406-455 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | ABL1 antibody ABL antibody JTK7 antibody Tyrosine-protein kinase ABL1 antibody Abelson murine leukemia viral oncogene homolog 1 antibody Abelson tyrosine-protein kinase 1 antibody Proto-oncogene c-Abl antibody p150 antibody ABL2 antibody ABLL antibody ARG antibody Abelson tyrosine-protein kinase 2 antibody Abelson murine leukemia vira antibody |
|---|---|
| Molecular Weight(MW) | 125(200kd BCR-ABL complex） kDa |
| Positive Control | Brain,Epithelium,Fibroblast,Lung,PCR rescued clones |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
