| Product Name | Actinin-α1/2/3/4 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ACTN1 antibody; Alpha-actinin-1 antibody; Alpha-actinin cytoskeletal isoform antibody; F-actin cross-linking protein antibody; Non-muscle alpha-actinin-1 antibody; ACTN2 antibody; Alpha-actinin-2 antibody; Alpha-actinin skeletal muscle isoform 2 antibody; F-actin cross-linking protein antibody; ACTN3 antibody; Alpha-actinin-3 antibody; A antibody; |
| Product description | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ACTN1/2/3/4. AA range:21-70 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | ACTN1 antibody Alpha-actinin-1 antibody Alpha-actinin cytoskeletal isoform antibody F-actin cross-linking protein antibody Non-muscle alpha-actinin-1 antibody ACTN2 antibody Alpha-actinin-2 antibody Alpha-actinin skeletal muscle isoform 2 antibody F-actin cross-linking protein antibody ACTN3 antibody Alpha-actinin-3 antibody A antibody |
|---|---|
| Molecular Weight(MW) | 75 kDa |
| Positive Control | Colon,Epithelium,Hepatocyte,Neuroblastoma,Placenta,Platelet,Skin,Tumor of tongue, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
