| Product Name | AF-4 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AFF1 antibody; AF4 antibody; FEL antibody; MLLT2 antibody; PBM1 antibody; AF4/FMR2 family member 1 antibody; ALL1-fused gene from chromosome 4 protein antibody; Protein AF-4 antibody; Protein FEL antibody; Proto-oncogene AF4 antibody; |
| Product description | This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AF4. AA range:1-50 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | AFF1 antibody AF4 antibody FEL antibody MLLT2 antibody PBM1 antibody AF4/FMR2 family member 1 antibody ALL1-fused gene from chromosome 4 protein antibody Protein AF-4 antibody Protein FEL antibody Proto-oncogene AF4 antibody |
|---|---|
| Molecular Weight(MW) | 130 kDa |
| SwissProt ID | P51825 |
|---|
| Positive Control | Epithelium,PCR rescued clones,Placenta, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
