| Product Name | Akt1/3 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AKT1 antibody; PKB antibody; RAC antibody; RAC-alpha serine/threonine-protein kinase antibody; Protein kinase B antibody; PKB antibody; Protein kinase B alpha antibody; PKB alpha antibody; Proto-oncogene c-Akt antibody; RAC-PK-alpha antibody; AKT3 antibody; PKBG antibody; RAC-gamma serine/threonine-protein kinase antibody; Protein kinase Akt-3 antibody; Protein ki antibody; |
| Product description | The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AKT1. AA range:406-455 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | AKT1 antibody PKB antibody RAC antibody RAC-alpha serine/threonine-protein kinase antibody Protein kinase B antibody PKB antibody Protein kinase B alpha antibody PKB alpha antibody Proto-oncogene c-Akt antibody RAC-PK-alpha antibody AKT3 antibody PKBG antibody RAC-gamma serine/threonine-protein kinase antibody Protein kinase Akt-3 antibody Protein ki antibody |
|---|---|
| Molecular Weight(MW) | 56 kDa |
| Positive Control | Epithelium,Eye,Foreskin,Muscle,Ovary,Placenta, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
