| Product Name | Arkadia |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RNF111 antibody; E3 ubiquitin-protein ligase Arkadia antibody; RING finger protein 111 antibody; |
| Product description | The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | RNF111 antibody E3 ubiquitin-protein ligase Arkadia antibody RING finger protein 111 antibody |
|---|---|
| Molecular Weight(MW) | 110 kDa |
| SwissProt ID | Q6ZNA4 |
|---|
| Positive Control | Amygdala,Brain,Colon,Endometrium,Placenta,Thymus,Tongue, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
