| Product Name | Ataxin-1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ATXN1 antibody; ATX1 antibody; SCA1 antibody; Ataxin-1 antibody; Spinocerebellar ataxia type 1 protein antibody; |
| Product description | The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Ataxin 1. AA range:742-791 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | ATXN1 antibody ATX1 antibody SCA1 antibody Ataxin-1 antibody Spinocerebellar ataxia type 1 protein antibody |
|---|---|
| Molecular Weight(MW) | 87 kDa |
| SwissProt ID | P54253 |
|---|
| Positive Control | Brain,Cerebellum,Skeletal muscle, |
|---|---|
| Application Notes | IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
