| Product Name | Ataxin-2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ATXN2 antibody; ATX2 antibody; SCA2 antibody; TNRC13 antibody; Ataxin-2 antibody; Spinocerebellar ataxia type 2 protein antibody; Trinucleotide repeat-containing gene 13 protein antibody; |
| Product description | This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The protein is primarily localized to the Golgi apparatus, with deletion of the Golgi and endoplasmic reticulum signals resulting in abnormal subcellular localization. In addition, the N-terminal region contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegener |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ATXN2. AA range:731-780 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | ATXN2 antibody ATX2 antibody SCA2 antibody TNRC13 antibody Ataxin-2 antibody Spinocerebellar ataxia type 2 protein antibody Trinucleotide repeat-containing gene 13 protein antibody |
|---|---|
| Molecular Weight(MW) | 140 kDa |
| SwissProt ID | Q99700 |
|---|
| Positive Control | Epithelium,PCR rescued clones,Trachea, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
