| Product Name | ATRX |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ATRX antibody; RAD54L antibody; XH2 antibody; Transcriptional regulator ATRX antibody; ATP-dependent helicase ATRX antibody; X-linked helicase II antibody; X-linked nuclear protein antibody; XNP antibody; Znf-HX antibody; |
| Product description | The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ATRX. AA range:111-160 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IF |
| IF:1:100-1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | ATRX antibody RAD54L antibody XH2 antibody Transcriptional regulator ATRX antibody ATP-dependent helicase ATRX antibody X-linked helicase II antibody X-linked nuclear protein antibody XNP antibody Znf-HX antibody |
|---|---|
| Molecular Weight(MW) | kDa |
| SwissProt ID | P46100 |
|---|
| Positive Control | Brain,Epithelium,Placenta, |
|---|---|
| Application Notes | IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
