| Product Name | AZ1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | OAZ1 antibody; OAZ antibody; Ornithine decarboxylase antizyme 1 antibody; ODC-Az antibody; |
| Product description | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms |
| Immunogen | The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | OAZ1 antibody OAZ antibody Ornithine decarboxylase antizyme 1 antibody ODC-Az antibody |
|---|---|
| Molecular Weight(MW) | kDa |
| SwissProt ID | P54368 |
|---|
| Positive Control | Brain,Fibroblast,Lymphoma, |
|---|---|
| Application Notes | IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
