| Product Name | Bag-4 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BAG4 antibody; SODD antibody; BAG family molecular chaperone regulator 4 antibody; BAG-4 antibody; Bcl-2-associated athanogene 4 antibody; Silencer of death domains antibody; |
| Product description | The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct |
| Immunogen | Synthesized peptide derived from the C-terminal region of human Bag-4. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | BAG4 antibody SODD antibody BAG family molecular chaperone regulator 4 antibody BAG-4 antibody Bcl-2-associated athanogene 4 antibody Silencer of death domains antibody |
|---|---|
| Molecular Weight(MW) | 50 kDa |
| SwissProt ID | O95429 |
|---|
| Positive Control | Brain,Leukemic T-cell, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
