| Product Name | BCAR3 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BCAR3 antibody; NSP2 antibody; SH2D3B antibody; Breast cancer anti-estrogen resistance protein 3 antibody; Novel SH2-containing protein 2 antibody; SH2 domain-containing protein 3B antibody; |
| Product description | Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BCAR3. AA range:761-810 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | BCAR3 antibody NSP2 antibody SH2D3B antibody Breast cancer anti-estrogen resistance protein 3 antibody Novel SH2-containing protein 2 antibody SH2 domain-containing protein 3B antibody |
|---|---|
| Molecular Weight(MW) | 92 kDa |
| SwissProt ID | O75815 |
|---|
| Positive Control | Epithelium,Kidney,Lung,Testis, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
