catalytic activity:ATP + a protein = ADP + a phosphoprotein. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'. Belongs to the protein kinase superfamily. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. Contains 1 protein kinase domain. subunit:Monomer. Interacts with the Axin complex.
Immunogen
The antiserum was produced against synthesized peptide derived from human CKI-alpha. AA range:126-175