| Product Name | COL25A1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | COL25A1 antibody; Collagen alpha-1(XXV) chain antibody; Alzheimer disease amyloid-associated protein antibody; AMY antibody; CLAC-P antibody; |
| Product description | This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Collagen XXV alpha1. AA range:101-150 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | COL25A1 antibody Collagen alpha-1(XXV) chain antibody Alzheimer disease amyloid-associated protein antibody AMY antibody CLAC-P antibody |
|---|---|
| Molecular Weight(MW) | 64 kDa |
| SwissProt ID | Q9BXS0 |
|---|
| Positive Control | Testis, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
