| Product Name | cPLA2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PLA2G4A antibody; CPLA2 antibody; PLA2G4 antibody; Cytosolic phospholipase A2 antibody; cPLA2 antibody; Phospholipase A2 group IVA antibody; |
| Product description | This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human c-PLA2. AA range:471-520 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | PLA2G4A antibody CPLA2 antibody PLA2G4 antibody Cytosolic phospholipase A2 antibody cPLA2 antibody Phospholipase A2 group IVA antibody |
|---|---|
| Molecular Weight(MW) | 110 kDa |
| SwissProt ID | P47712 |
|---|
| Positive Control | Epithelium,Platelet, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
