| Product Name | Cystatin B |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CSTB antibody; CST6 antibody; STFB antibody; Cystatin-B antibody; CPI-B antibody; Liver thiol proteinase inhibitor antibody; Stefin-B antibody; |
| Product description | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG rep |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Stefin B. AA range:49-98 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanRat |
| Concentration | 1mg/ml |
| Alternative Names | CSTB antibody CST6 antibody STFB antibody Cystatin-B antibody CPI-B antibody Liver thiol proteinase inhibitor antibody Stefin-B antibody |
|---|---|
| Molecular Weight(MW) | 11 kDa |
| SwissProt ID | P04080 |
|---|
| Positive Control | Cerebellum,Placenta, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
