| Product Name | DOC-1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CDK2AP1 antibody; CDKAP1 antibody; DOC1 antibody; Cyclin-dependent kinase 2-associated protein 1 antibody; CDK2-associated protein 1 antibody; Deleted in oral cancer 1 antibody; DOC-1 antibody; Putative oral cancer suppressor antibody; |
| Product description | The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDKAP1. AA range:51-100 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | CDK2AP1 antibody CDKAP1 antibody DOC1 antibody Cyclin-dependent kinase 2-associated protein 1 antibody CDK2-associated protein 1 antibody Deleted in oral cancer 1 antibody DOC-1 antibody Putative oral cancer suppressor antibody |
|---|---|
| Molecular Weight(MW) | 20 kDa |
| SwissProt ID | O14519 |
|---|
| Positive Control | Skin,Testis, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
