| Product Name | ErbB-3 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ERBB3 antibody; HER3 antibody; Receptor tyrosine-protein kinase erbB-3 antibody; Proto-oncogene-like protein c-ErbB-3 antibody; Tyrosine kinase-type cell surface receptor HER3 antibody; |
| Product description | This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the m |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HER3. AA range:1256-1305 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | ERBB3 antibody HER3 antibody Receptor tyrosine-protein kinase erbB-3 antibody Proto-oncogene-like protein c-ErbB-3 antibody Tyrosine kinase-type cell surface receptor HER3 antibody |
|---|---|
| Molecular Weight(MW) | 148 kDa |
| SwissProt ID | P21860 |
|---|
| Positive Control | Placenta,Skin,Thalamus, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
