| Product Name | ERK 8 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MAPK15 antibody; ERK7 antibody; ERK8 antibody; Mitogen-activated protein kinase 15 antibody; MAP kinase 15 antibody; MAPK 15 antibody; Extracellular signal-regulated kinase 7 antibody; ERK-7 antibody; Extracellular signal-regulated kinase 8 antibody; ERK-8 antibody; |
| Product description | catalytic activity:ATP + a protein = ADP + a phosphoprotein. domain:The N-terminal region (1-20) is the minimal region necessary for ubiquitination and further proteosomal degradation. domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. enzyme regulation:Activated by threonine and tyrosine phosphorylation. Inhibited by dual specificity phosphatases, such as DUSP1. In vitro, phosphorylates MBP. PTM:Dually phosphorylated on Thr-175 and Tyr-177, which activates the enzyme. Autophosphorylated on threonine and tyrosine residues in vitro. PTM:Ubiquitinated. Ubiquitination may allow its tight kinase activity regulation and rapid turnover. May be ubiquitinated by a SCF E3 ligase. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. Contains 1 protein kinase domain. subunit:Interacts with CSK/c-Src, ABL1, RET and TGFB1I1. tissue specificity:Widely expressed with a maximal expression in lung and kidney. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAPK15. AA range:141-190 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | MAPK15 antibody ERK7 antibody ERK8 antibody Mitogen-activated protein kinase 15 antibody MAP kinase 15 antibody MAPK 15 antibody Extracellular signal-regulated kinase 7 antibody ERK-7 antibody Extracellular signal-regulated kinase 8 antibody ERK-8 antibody |
|---|---|
| Molecular Weight(MW) | 60 kDa |
| SwissProt ID | Q8TD08 |
|---|
| Positive Control | Brain,Medulla oblongata,Testis, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
