Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli. PTM:Phosphorylated. Contains 1 FHA domain. Contains 1 fork-head DNA-binding domain. subunit:Interacts with SIN3B to form a complex which represses transcription. tissue specificity:Expressed both developing and adult tissues. In adults, significant expression is seen in tumors of the brain, colon and lymph node.
Immunogen
The antiserum was produced against synthesized peptide derived from human FOXK1. AA range:681-730