| Product Name | Frizzled-6 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FZD6 antibody; Frizzled-6 antibody; Fz-6 antibody; hFz6 antibody; |
| Product description | This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide., |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FZD6. AA range:116-165 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | FZD6 antibody Frizzled-6 antibody Fz-6 antibody hFz6 antibody |
|---|---|
| Molecular Weight(MW) | 79 kDa |
| SwissProt ID | O60353 |
|---|
| Positive Control | Fetal lung,Placenta,Uterine endothelium, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
