| Product Name | FRS2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | FRS2 antibody; Fibroblast growth factor receptor substrate 2 antibody; FGFR substrate 2 antibody; FGFR-signaling adaptor SNT antibody; Suc1-associated neurotrophic factor target 1 antibody; SNT-1 antibody; |
| Product description | Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. PTM:Phosphorylated on tyrosine residues upon stimulation by NGF. PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. sequence caution:Translated as stop. Contains 1 IRS-type PTB domain. subcellular location:Cytoplasmic, membrane-bound. subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FRS2. AA range:162-211 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | FRS2 antibody Fibroblast growth factor receptor substrate 2 antibody FGFR substrate 2 antibody FGFR-signaling adaptor SNT antibody Suc1-associated neurotrophic factor target 1 antibody SNT-1 antibody |
|---|---|
| Molecular Weight(MW) | 65 kDa |
| SwissProt ID | Q8WU20 |
|---|
| Positive Control | Hippocampus,Placenta,Uterus, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
