| Product Name | GAD-65/67 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GAD1 antibody; GAD antibody; GAD67 antibody; Glutamate decarboxylase 1 antibody; 67 kDa glutamic acid decarboxylase antibody; GAD-67 antibody; Glutamate decarboxylase 67 kDa isoform antibody; GAD2 antibody; GAD65 antibody; Glutamate decarboxylase 2 antibody; 65 kDa glutamic acid decarboxylase antibody; GAD-65 antibody; Glutamate decarboxylase 65 antibody; |
| Product description | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GAD1/2. AA range:545-594 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | GAD1 antibody GAD antibody GAD67 antibody Glutamate decarboxylase 1 antibody 67 kDa glutamic acid decarboxylase antibody GAD-67 antibody Glutamate decarboxylase 67 kDa isoform antibody GAD2 antibody GAD65 antibody Glutamate decarboxylase 2 antibody 65 kDa glutamic acid decarboxylase antibody GAD-65 antibody Glutamate decarboxylase 65 antibody |
|---|---|
| Molecular Weight(MW) | 65 kDa |
| Positive Control | Brain,Pancreatic islet,Testis, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
