| Product Name | GLCNE |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GNE antibody; GLCNE antibody; Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase antibody; UDP-GlcNAc-2-epimerase/ManAc kinase antibody; |
| Product description | The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GNE. AA range:592-641 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | GNE antibody GLCNE antibody Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase antibody UDP-GlcNAc-2-epimerase/ManAc kinase antibody |
|---|---|
| Molecular Weight(MW) | 80 kDa |
| SwissProt ID | Q9Y223 |
|---|
| Positive Control | Liver,Small intestine,Tongue, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
