Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. Belongs to the G-protein coupled receptor 1 family. tissue specificity:Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain.
Immunogen
The antiserum was produced against synthesized peptide derived from human GPR17. AA range:196-245