| Product Name | GRIP-1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NCOA2 antibody; BHLHE75 antibody; TIF2 antibody; Nuclear receptor coactivator 2 antibody; NCoA-2 antibody; Class E basic helix-loop-helix protein 75 antibody; bHLHe75 antibody; Transcriptional intermediary factor 2 antibody; hTIF2 antibody; |
| Product description | The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NCoA2. AA range:702-751 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:100-1:300 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | NCOA2 antibody BHLHE75 antibody TIF2 antibody Nuclear receptor coactivator 2 antibody NCoA-2 antibody Class E basic helix-loop-helix protein 75 antibody bHLHe75 antibody Transcriptional intermediary factor 2 antibody hTIF2 antibody |
|---|---|
| Molecular Weight(MW) | kDa |
| SwissProt ID | Q15596 |
|---|
| Positive Control | Epithelium,Placenta,Spinal cord,Testis, |
|---|---|
| Application Notes | IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
