| Product Name | Hexb |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HEXB antibody; HCC7 antibody; Beta-hexosaminidase subunit beta antibody; Beta-N-acetylhexosaminidase subunit beta antibody; Hexosaminidase subunit B antibody; Cervical cancer proto-oncogene 7 protein antibody; HCC-7 antibody; N-acetyl-beta-glucosaminidase subunit beta antibody; |
| Product description | Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HEXB. AA range:481-530 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | HEXB antibody HCC7 antibody Beta-hexosaminidase subunit beta antibody Beta-N-acetylhexosaminidase subunit beta antibody Hexosaminidase subunit B antibody Cervical cancer proto-oncogene 7 protein antibody HCC-7 antibody N-acetyl-beta-glucosaminidase subunit beta antibody |
|---|---|
| Molecular Weight(MW) | 63 kDa |
| SwissProt ID | P07686 |
|---|
| Positive Control | Liver,Skin, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
