| Product Name | HGK |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MAP4K4 antibody; HGK antibody; KIAA0687 antibody; NIK antibody; Mitogen-activated protein kinase kinase kinase kinase 4 antibody; HPK/GCK-like kinase HGK antibody; MAPK/ERK kinase kinase kinase 4 antibody; MEK kinase kinase 4 antibody; MEKKK 4 antibody; Nck-interacting kinase antibody; |
| Product description | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MEKKK 4. AA range:406-455 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIF |
| WB:1:500-1:2000 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | MAP4K4 antibody HGK antibody KIAA0687 antibody NIK antibody Mitogen-activated protein kinase kinase kinase kinase 4 antibody HPK/GCK-like kinase HGK antibody MAPK/ERK kinase kinase kinase 4 antibody MEK kinase kinase 4 antibody MEKKK 4 antibody Nck-interacting kinase antibody |
|---|---|
| Molecular Weight(MW) | 142 kDa |
| SwissProt ID | O95819 |
|---|
| Positive Control | Brain,Epithelium,Glioblastoma,Macrophage,Testis, |
|---|---|
| Application Notes | WB:1:500-1:2000 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
