| Product Name | HLA-DOβ |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HLA-DOB antibody; HLA class II histocompatibility antigen antibody; DO beta chain antibody; MHC class II antigen DOB antibody; |
| Product description | HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HLA-DOB. AA range:1-50 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | HLA-DOB antibody HLA class II histocompatibility antigen antibody DO beta chain antibody MHC class II antigen DOB antibody |
|---|---|
| Molecular Weight(MW) | 30 kDa |
| SwissProt ID | P13765 |
|---|
| Positive Control | B-cell, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
