| Product Name | HM74 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | HCAR3 antibody; GPR109B antibody; HCA3 antibody; HM74B antibody; NIACR2 antibody; Hydroxycarboxylic acid receptor 3 antibody; G-protein coupled receptor 109B antibody; G-protein coupled receptor HM74 antibody; G-protein coupled receptor HM74B antibody; Niacin receptor 2 antibody; Nicotinic acid receptor 2 antibody; HCAR2 antibody; GPR109A antibody; HCA2 antibody; antibody; |
| Product description | developmental stage:Expression in neutrophils occurs in the late terminal differentiation phase. Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. miscellaneous:The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. Belongs to the G-protein coupled receptor 1 family. tissue specificity:Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GPR109. AA range:285-334 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIF |
| WB:1:500-1:2000 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | HCAR3 antibody GPR109B antibody HCA3 antibody HM74B antibody NIACR2 antibody Hydroxycarboxylic acid receptor 3 antibody G-protein coupled receptor 109B antibody G-protein coupled receptor HM74 antibody G-protein coupled receptor HM74B antibody Niacin receptor 2 antibody Nicotinic acid receptor 2 antibody HCAR2 antibody GPR109A antibody HCA2 antibody antibody |
|---|---|
| Molecular Weight(MW) | 45 kDa |
| Positive Control | Pancreas, |
|---|---|
| Application Notes | WB:1:500-1:2000 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
