| Product Name | HURP |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DLGAP5 antibody; DLG7 antibody; KIAA0008 antibody; Disks large-associated protein 5 antibody; DAP-5 antibody; Discs large homolog 7 antibody; Disks large-associated protein DLG7 antibody; Hepatoma up-regulated protein antibody; HURP antibody; |
| Product description | developmental stage:Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells. Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells. PTM:Ubiquitinated, leading to its degradation. Belongs to the SAPAP family. subcellular location:Localizes to the spindle poles in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells. subunit:Interacts with CDC2. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDC2/Cyclin B-phosphorylation dependent manner. Interacts with CDH1. tissue specificity:Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DLGAP5. AA range:791-840 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500-1:2000 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | DLGAP5 antibody DLG7 antibody KIAA0008 antibody Disks large-associated protein 5 antibody DAP-5 antibody Discs large homolog 7 antibody Disks large-associated protein DLG7 antibody Hepatoma up-regulated protein antibody HURP antibody |
|---|---|
| Molecular Weight(MW) | 95 kDa |
| SwissProt ID | Q15398 |
|---|
| Positive Control | Bone marrow,Epithelium,Eye,Lung,T cells, |
|---|---|
| Application Notes | WB:1:500-1:2000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
