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ICAD

Catalog Number:OM634814
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OM634814
Discount Price
OM634814-100ul
1~2 Week
100ul
OM634814-50ul
50ul
OM634814-20ul
20ul
1~2 Week
Product Profile
Product Name ICAD
Antibody Type Primary Antibodies
Product description

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Immunogen The antiserum was produced against synthesized peptide derived from human DFFA. AA range:151-200
Key Feature
Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications IFIHCWB
WB:1:500-1:2000
IHC:1:100-1:300
IF:1:100-1:500
Species Reactivity HumanMouseRat
Concentration 1mg/ml
Target Information
Alternative Names DFFA antibody
DFF1 antibody
DFF45 antibody
H13 antibody
DNA fragmentation factor subunit alpha antibody
DNA fragmentation factor 45 kDa subunit antibody
DFF-45 antibody
Inhibitor of CAD antibody
ICAD antibody
Molecular Weight(MW) 36 kDa
Database Links
SwissProt ID O00273
Application
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WB

Expression results of key genes (a) related to the antibacterial mechanism of PSF, PSF/GO, and PSF/GO/Ag (0.7) fibrous membranes against S. aureus after 24 h of antibacterial treatment.
Positive Control Breast,Coronary artery,Epithelium,Eye,Kidney,Skeletal muscle,
Application Notes WB:1:500-1:2000
IHC:1:100-1:300
IF:1:100-1:500
Additional Information
Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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References(1)