| Product Name | IRE1α/β |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ERN2 antibody; IRE2 antibody; Serine/threonine-protein kinase/endoribonuclease IRE2 antibody; Endoplasmic reticulum-to-nucleus signaling 2 antibody; Inositol-requiring protein 2 antibody; hIRE2p antibody; Ire1-beta antibody; IRE1b antibody; |
| Product description | catalytic activity:ATP + a protein = ADP + a phosphoprotein. cofactor:Magnesium. enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain. Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. PTM:Autophosphorylated. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 KEN domain. Contains 1 protein kinase domain. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ERN2. AA range:841-890 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCIF |
| IHC:1:100-1:300 IF:1:100-1:500 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | ERN2 antibody IRE2 antibody Serine/threonine-protein kinase/endoribonuclease IRE2 antibody Endoplasmic reticulum-to-nucleus signaling 2 antibody Inositol-requiring protein 2 antibody hIRE2p antibody Ire1-beta antibody IRE1b antibody |
|---|---|
| Molecular Weight(MW) | kDa |
| SwissProt ID | Q76MJ5 |
|---|
| Positive Control | Fetal brain,Fetal lung fibroblast, |
|---|---|
| Application Notes | IHC:1:100-1:300 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
