| Product description |
catalytic activity:ATP + a protein = ADP + a phosphoprotein. Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK. PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 protein kinase domain. subcellular location:Also localized to the peripheral cell membrane. subunit:Self-associates. tissue specificity:Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. |