| Product Name | LATS1/2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | LATS1 antibody; WARTS antibody; Serine/threonine-protein kinase LATS1 antibody; Large tumor suppressor homolog 1 antibody; WARTS protein kinase antibody; h-warts antibody; LATS2 antibody; KPM antibody; Serine/threonine-protein kinase LATS2 antibody; Kinase phosphorylated during mitosis protein antibody; Large tumor suppressor ho antibody; |
| Product description | The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LATS1/2. AA range:1041-1090 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | LATS1 antibody WARTS antibody Serine/threonine-protein kinase LATS1 antibody Large tumor suppressor homolog 1 antibody WARTS protein kinase antibody h-warts antibody LATS2 antibody KPM antibody Serine/threonine-protein kinase LATS2 antibody Kinase phosphorylated during mitosis protein antibody Large tumor suppressor ho antibody |
|---|---|
| Molecular Weight(MW) | 130-140 kDa |
| Positive Control | Brain,Endometrium,Epithelium,Fetal brain,Lung, |
|---|---|
| Application Notes | IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
