| Product description |
caution:It is uncertain whether Met-1 or Met-23 is the initiator. domain:The elongin BC complex binding domain is also known as BC-box with the consensus-L-x(3)-C-x(3)-[AILV]. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. pathway:Protein modification; protein ubiquitination. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. sequence caution:Translation N-terminally extended. Contains 7 LRR (leucine-rich) repeats. subunit:Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2. |