| Product Name | MB67 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NR1I3 antibody; CAR antibody; Nuclear receptor subfamily 1 group I member 3 antibody; Constitutive activator of retinoid response antibody; Constitutive active response antibody; Constitutive androstane receptor antibody; CAR antibody; Orphan nuclear receptor MB67 antibody; |
| Product description | This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human NR1I3. AA range:71-120 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | NR1I3 antibody CAR antibody Nuclear receptor subfamily 1 group I member 3 antibody Constitutive activator of retinoid response antibody Constitutive active response antibody Constitutive androstane receptor antibody CAR antibody Orphan nuclear receptor MB67 antibody |
|---|---|
| Molecular Weight(MW) | 35 kDa |
| SwissProt ID | Q14994 |
|---|
| Positive Control | Liver,PCR rescued clones, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
