| Product Name | MC1-R |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MC1R antibody; MSHR antibody; Melanocyte-stimulating hormone receptor antibody; MSH-R antibody; Melanocortin receptor 1 antibody; MC1-R antibody; |
| Product description | This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in de |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MSHR. AA range:268-317 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIF |
| WB:1:500-1:2000 IF:1:100-1:500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | MC1R antibody MSHR antibody Melanocyte-stimulating hormone receptor antibody MSH-R antibody Melanocortin receptor 1 antibody MC1-R antibody |
|---|---|
| Molecular Weight(MW) | 35 kDa |
| SwissProt ID | Q01726 |
|---|
| Positive Control | Brain,Cajal-Retzius cell,Fetal brain cortex,Lung,Mammary cancer,Skin,Thyroid, |
|---|---|
| Application Notes | WB:1:500-1:2000 IF:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
