| Product Name | MDMX |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MDM4 antibody; MDMX antibody; Protein Mdm4 antibody; Double minute 4 protein antibody; Mdm2-like p53-binding protein antibody; Protein Mdmx antibody; p53-binding protein Mdm4 antibody; |
| Product description | This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MDM4. AA range:336-385 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500-1:2000 IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | MDM4 antibody MDMX antibody Protein Mdm4 antibody Double minute 4 protein antibody Mdm2-like p53-binding protein antibody Protein Mdmx antibody p53-binding protein Mdm4 antibody |
|---|---|
| Molecular Weight(MW) | 45 kDa |
| SwissProt ID | O15151 |
|---|
| Positive Control | Brain,Colon tumor,Gastric mucosa,Mammary cancer,Testis,Uterus, |
|---|---|
| Application Notes | WB:1:500-1:2000 IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
