| Product Name | MEK Kinase-4 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MAP3K4 antibody; KIAA0213 antibody; MAPKKK4 antibody; MEKK4 antibody; MTK1 antibody; Mitogen-activated protein kinase kinase kinase 4 antibody; MAP three kinase 1 antibody; MAPK/ERK kinase kinase 4 antibody; MEK kinase 4 antibody; MEKK 4 antibody; |
| Product description | The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MAP3K4. AA range:1281-1330 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:100-1:300 |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | MAP3K4 antibody KIAA0213 antibody MAPKKK4 antibody MEKK4 antibody MTK1 antibody Mitogen-activated protein kinase kinase kinase 4 antibody MAP three kinase 1 antibody MAPK/ERK kinase kinase 4 antibody MEK kinase 4 antibody MEKK 4 antibody |
|---|---|
| Molecular Weight(MW) | kDa |
| SwissProt ID | Q9Y6R4 |
|---|
| Positive Control | Bone marrow,Fetal liver,Liver,Skeletal muscle, |
|---|---|
| Application Notes | IHC:1:100-1:300 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
